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A novel, immunotherapy-based approach for the treatment of relapsed/refractory multiple myeloma (RRMM): Updated phase 1b results for daratumumab in combination with teclistamab (a BCMA x CD3 bispecific antibody)

Marmentini, C., Branco, R

By inhibiting NNMT, 5-Amino-1MQ prevents the methylation of nicotinamide, allowing more substrate to enter the NAD+ salvage pathway

The EMT cell transcriptome is characterized by the expression of proteins with multiple functions, such as growth factors and corresponding protein factor receptors (TGF, HGF, HGFR), accessory transcription factors (Wnt, Notch, NFkB), integrin receptors, proteoglycan joint receptors CD44, and glucose-6-phosphate isomerase (GPI) (173)